Structural Biology

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By studying cells and molecules in 3D, FNL focuses its research and development activities to understanding the molecular basis of cell organization, invasion, and differentiation using live, 3D tissue culture models. Electron microscopy capabilities are used to assist investigators in exploring new avenues of research to enhance knowledge of biological systems.

Nanotechnology Characterization

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The Nanotechnology Characterization Laboratory (NCL) is a national resource for cancer researchers to test nanotechnologies intended for cancer therapies and diagnostics. The NCL reduces suffering and death from cancer by accelerating the transition of basic nanoscale particles and devices into clinical applications.

RAS Initiative

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More than 30 percent of all human cancers- including 95 percent of pancreatic cancers and 45 percent of colorectal cancers- are driven by mutations of the RAS family of genes. NCI established the RAS initiative in 2013 to explore innovative approaches for attacking the proteins encoded by the mutant form of RAS genes and to … Continue reading RAS Initiative

Biomedical Imaging

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The Advanced Biomedical Computing Center (ABCC) supports scientific research at FNL through state-of-the-art image analysis and visualization, nanoinformatics, proteomic analysis, bioinformatics, and mathematical simulation and modeling. The technology helps researchers accelerate their work to determine more powerful cancer treatments.

High-performance biomedical computing

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Through collaboration with the National Cancer Institute and Department of Energy (DOE), The Frederick National Lab plays a significant role in expanding the use of high-performance computing in cancer research. The partnership supports the government’s Beau Biden Cancer Moonshot℠ and Precision Medicine initiatives by developing high-performance computing capabilities to meet the challenges of modeling problems in cancer … Continue reading High-performance biomedical computing

Molecular characterization

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The Molecular Characterization Laboratory (MoCha) provides scientific evidence to improve patient outcomes by translating information from the characterization of molecular alterations in patients’ tumors. MoCha has played a central role in the NCI-MATCH clinical trial to test cancer drugs using the newest tools of precision medicine to identify best treatment for patients based on the … Continue reading Molecular characterization

Nanotechnology characterization, formulation

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The Nanotechnology Characterization Laboratory (NCL) characterizes nanoparticles’ physical and chemical attributes, their in vitro biological properties, and their in vivo compatibility through preclinical toxicology, pharmacology, and efficacy studies. The NCL has characterized more than 360 different nanomedicine products for researchers worldwide, and it has partnered with several pharmaceutical companies for nanotech reformulation and characterization efforts.

Cryo-electron microscopy

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The Frederick National Lab is home to the National Cyro-Electron Microscopy Facility (NCEF), a user facility to provide cancer researchers access to the latest technology for high resolution imaging. These microscope and detector technologies are critical for obtaining the highest resolution images of biological structures. This facility meets the needs of cancer researchers who are … Continue reading Cryo-electron microscopy